A 4-year-old girl has had puffy eyelids each morning for two weeks and now has swollen legs and a distended abdomen. Her blood pressure is 96/58 mmHg. Urine testing shows protein 4+ and no blood, and microscopy shows no red cells or casts. Her urinary protein is almost entirely albumin. Plasma albumin is 16 g/L and creatinine 32 micromol/L.

A defect in which one of the following components of the renal corpuscle best accounts for this girl's urinary findings?

Filed under paediatrics › nephrology › nephrotic-syndrome › nephrotic-syndrome

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