Year 4common
A 61-year-old man presents to the emergency department with a 6-hour history of hematemesis and melena. He reports a long-standing history of osteoarthritis, for which he takes over-the-counter ibuprofen most days. He does not drink alcohol and has no known liver disease.
He is haemodynamically stable.
Which of the following best describes the mechanism behind his most likely cause of his symptoms?